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REDUCE-IT CV outcomes trial of icosapent ethyl to continue

September 20, 2014

Amarin Corporation plc announced that it will complete the REDUCE-IT CV outcomes study of icosapent ethyl despite difficulties in obtaining FDA approval for an expanded indication for the drug for the treatment of patients on statin therapy with elevated triglycerides.

The multinational, prospective, double blind trial currently has over 7,000 patients enrolled, with enrollment projected to be completed during 2015. All patients have high or elevated triglycerides despite stable statin therapy, and have either current CHD or risk factors for CHD. Patients will be randomly assigned to either 4 g icosapent ethyl (Vascepa, Amarin) or placebo, with a composite primary endpoint of major adverse CV events, including CV-related death, nonfatal MI, stroke, coronary revascularization or hospitalization due to unstable angina as a result of myocardial ischemia, according to a press release.

Meeting News Coverage

Stroke risk doubled in permanent AF vs. paroxysmal AF among nonanticoagulated patients

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BARCELONA, Spain — Among patients with atrial fibrillation who are taking aspirin but not an anticoagulant, those with permanent atrial fibrillation were twice as…
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Bernard DeBruyne, MD, PhD, discusses FAMOUS NSTEMI results

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Managing Acute Ischemic Stroke in the Emergency Department: Two Decades of Progress

This activity is supported by an educational grant from Genentech.

According to the American Heart Association Heart Disease and Stroke Statistics 2013 Update, approximately 795,000…
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Meeting News Coverage Video
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Bernard DeBruyne, MD, PhD, discusses FAMOUS NSTEMI results

September 19, 2014
BARCELONA, SPAIN — In this video, Bernard De Bruyne, MD, PhD, of the Cardiovascular Center Aalst, Onze Lieve…
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Acute Coronary Syndrome Portal

The ACS Portal is a center for the latest information on ACS. Learn from leading experts as they provide perspective on…
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