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Confounding factors may partially explain results of SYMPLICITY HTN-3

December 19, 2014

Post-hoc analyses derived from patient subgroups indicated several potential confounding factors that may help explain the unexpected BP results in the control and intervention groups from the SYMPLICITY HTN-3 trial, researchers reported.

SYMPLICITY HTN-3 evaluated the Symplicity renal denervation system (Medtronic) in 535 patients with treatment-resistant hypertension. Despite positive results from earlier studies, SYMPLICTY HTN-3 showed no difference in the primary endpoint of office systolic BP change at 6 months between patients assigned renal denervation and those assigned a sham procedure.

In the Journals

Incidence of MI, stroke increased in high-impact areas after Hurricane Sandy

December 18, 2014
After Hurricane Sandy in 2012, the incidence of MI and stroke increased in New Jersey regions hit hardest by the storm, according to a new report.Researchers at Rutgers…
Thomas Frieden

CDC's 10 most important public health challenges of 2014

December 18, 2014
In a year that has been fraught with public health crises, the CDC has had more than its share of important work to do. While 2014’s Ebola epidemic dominated…
Mehdi H. Shishehbor, DO, MPH, PhD In the Journals

Researchers observe effect of single tibial artery revascularization on microcirculation

December 18, 2014
Single tibial artery revascularization was associated with similar improvements in dorsal and plantar microcirculation, concluded new data. Furthermore, roughly half of…
In the Journals

MicroRNA profiling could be biomarker of heart transplant rejection

December 18, 2014
Expression of microRNA could be a noninvasive biomarker of heart transplant rejection, according to recent study data.Researchers identified four microRNAs with…
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CME
Challenges and Opportunities in the Treatment of Acute Ischemic Stroke: Key Points for the Emergency Physician

Challenges and Opportunities in the Treatment of Acute Ischemic Stroke

This activity is supported by an educational grant from Genentech.

According to the American Heart Association Heart Disease and Stroke Statistics – 2013 Update, approximately 795,000…
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Healio AHA2014 Bhatt1 th

VIDEO: Deepak L. Bhatt, MD, MPH, discusses 'practice-changing' IMPROVE-IT results

December 14, 2014
CHICAGO — The "practice-changing" results from the IMPROVE-IT trial presented at the American Heart Association…
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CME
Risk Management in the Cardiovascular Disease Arena

Risk Management in the Cardiovascular Disease Arena: Focus on Glycemic Control

This activity is supported by an educational grant from Genentech.

Among the multiple comorbidities and complications that are associated with type 2 diabetes mellitus (T2DM)…
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