August 4, 2015
Older patients with atrial fibrillation who received triple therapy consisting of aspirin, clopidogrel and warfarin at discharge after PCI for acute MI had a similar risk for major adverse cardiac events at 2 years, but higher rates of major bleeding compared with patients who received aspirin and clopidogrel only.
Researchers analyzed 4,959 patients aged 65 years or older from the Acute Coronary Treatment and Intervention Outcomes Network Registry–Get With the Guidelines. All patients had AF and underwent coronary stenting after acute MI between 2007 and 2010. The primary efficacy outcome was MACE, defined as death, MI-related readmission or stroke, at 2 years. The primary safety outcome was readmission for bleeding at 2 years. Patients were stratified by whether they received dual antiplatelet therapy (DAPT) or DAPT plus warfarin at discharge.