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TOPCAT: Spironolactone effectiveness differed by region

November 24, 2014

CHICAGO — The TOPCAT trial to show benefits for spironolactone in patients with HF with preserved ejection fraction was neutral overall, but the effectiveness of the drug varied by region, according to results of a post-hoc analysis.

Among those studied, patients from the United States, Argentina, Brazil and Canada showed a better response to spironolactone compared with patients from the Republic of Georgia and Russia, Marc A. Pfeffer, MD, PhD, FACEP, FAHA, the Dzau professor of medicine at Harvard University Medical School and the cardiovascular division of Brigham & Women’s Hospital, said at the American Heart Association Scientific Sessions.

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