Cardiology

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Triple therapy has similar outcomes, more bleeding than dual therapy in older patients

August 4, 2015

Older patients with atrial fibrillation who received triple therapy consisting of aspirin, clopidogrel and warfarin at discharge after PCI for acute MI had a similar risk for major adverse cardiac events at 2 years, but higher rates of major bleeding compared with patients who received aspirin and clopidogrel only.

Researchers analyzed 4,959 patients aged 65 years or older from the Acute Coronary Treatment and Intervention Outcomes Network Registry–Get With the Guidelines. All patients had AF and underwent coronary stenting after acute MI between 2007 and 2010. The primary efficacy outcome was MACE, defined as death, MI-related readmission or stroke, at 2 years. The primary safety outcome was readmission for bleeding at 2 years. Patients were stratified by whether they received dual antiplatelet therapy (DAPT) or DAPT plus warfarin at discharge.

In the Journals

AHA: Social factors could reverse trend of declining US deaths from heart disease, stroke

August 3, 2015
Social determinants such as education, environment, income and race/ethnicity have the potential to reverse the trend of declining mortality from MI, stroke and other…
In the Journals

Chronic HCV influences subclinical CVD

August 3, 2015
A link between chronic hepatitis C virus infection and subclinical cardiovascular disease indicated a need for thorough and ongoing cardiovascular risk assessments among…
In the Journals

Women, black adults face greater loss of life expectancy after MI

August 3, 2015
After an acute MI, black patients lost more of their expected life years than white patients, and women lost more of their expected life years than men, researchers…
Jagat Narula, MD, PhD In the Journals

World Heart Federation outlines roadmaps to reduce CVD globally

August 3, 2015
Widespread implementation of strategies to improve CV secondary prevention, hypertension and tobacco control is essential to achieve the World Heart Federation goal of…
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CME
PCI in ACS: Deciding Among Clopidogrel, Prasugrel, or Ticagrelor

PCI in ACS: Deciding Among Clopidogrel, Prasugrel, or Ticagrelor

This activity is supported by an educational grant from Daiichi Sankyo, Inc. and Lilly USA, LLC

It is estimated that in the United States, each year, over 780,000 persons will experience an acute coronary syndrome…
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Video
VIDEO: Joseph Rossano, MD, MS, discusses benefits of VADs for children with advanced HF

VIDEO: Joseph Rossano, MD, MS, discusses benefits of VADs for children with advanced HF

July 17, 2015
PHILADELPHIA — In this video, Joseph Rossano, MD, MS, FAAP, FAAC, medical director of HF/transplantation at…
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CME
Highlights from Lipid Forum 2015™: Focus on Hypertriglyceridemia

Highlights from Lipid Forum 2015®: Focus on Hypertriglyceridemia

This activity is supported by an educational grant from AstraZeneca.

Hypertriglyceridemia is a highly prevalent yet modifiable risk factor for atherosclerotic disease, pancreatitis, and…
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