Acknowledgements
Contributing Authors
Introduction
SECTION 1 Basic Principles
Chapter 1 Principles of Clinical Epidemiology
Annette C. Moll, Michiel R. de Boer, and Lex M. Bouter
Chapter 2 Cancer Etiology
Evelyn X. Fu and Arun D. Singh
Chapter 3A Cancer Pathology
Stefan Seregard and Charlotta All-Ericsson
Chapter 3B Cancer Angiogenesis
Werner Wackernagel, Lynn Schoenfield, and Arun D. Singh
Chapter 4 Cancer Immunology
Martine J. Jager, Jihan Dennaoui, and Willem Maat
Chapter 5 Cancer Genetics
J. William Harbour and Michael D. Onken
Chapter 6 Principles of Cryotherapy
Dan S. Gombos
Chapter 7 Principles of Laser Therapy
Stefan Sacu and Ursula Schmidt-Erfurth
Chapter 8 Principles of Radiation Therapy
Carryn Anderson, Peter Fleming, Allan Wilkinson, and Arun D. Singh
Chapter 9 Ocular Complications of Radiotherapy
Mehran Taban, Mehryar Taban, James P. Bolling, and Arun D. Singh
Chapter 10 Principles of Chemotherapy
Michael Levien, Jennifer Gravette, and Joanne Hilden
Chapter 11 Counseling Patients With Cancer
Sharon Cook and Bertil E. Damato
SECTION 2 Eyelid Tumors
Chapter 12 Examination Techniques
Julian D. Perry
Chapter 13 Classification and Differential Diagnosis of Eyelid Tumors
Jacob Pe’er
Chapter 14 Benign Epidermal Tumors
Edoardo Midena, Valentina de Belvis, Lynn Schoenfield, and Arun D. Singh
Chapter 15 Basal Cell Carcinoma
Mordechai Rosner
Chapter 16 Squamous Cell Carcinoma
Mordechai Rosner
Chapter 17 Sebaceous Gland Carcinoma
Mordechai Rosner
Chapter 18 Melanoma of the Eyelid
Jacob Pe’er and Robert Folberg
Chapter 19 Eyelid Adnexal Tumors
Karin U. Loeffler
Chapter 20 Eyelid Stromal Tumors
Geeta K. Vemuganti and Santosh G. Honavar
Chapter 21 Surgical Techniques
Jennifer I. Hui and David T. Tse
Chapter 22 Systemic Associations of Eyelid Tumors
Arun D. Singh and Elias I. Traboulsi
SECTION 3 Conjunctival and Corneal Tumors
Chapter 23 Examination Techniques, Classification, and Differential Diagnosis of Conjunctival and Corneal Tumors 51
Jacob Pe’er
Chapter 24 Benign Conjunctival Tumors
Jacob Pe’er
Chapter 25 Ocular Surface Squamous Neoplasia
Jacob Pe’er and Joseph Frucht-Pery
Chapter 26 Primary Acquired Melanosis
Jacob Pe’er and Robert Folberg
Chapter 27 Conjunctival Melanoma
Jacob Pe’er and Robert Folberg
Chapter 28 Conjunctival Stromal Tumors
Jacob Pe’er
Chapter 29 Surgical Techniques
Anat Galor, Bennie H. Jeng, and Arun D. Singh
Chapter 30 Systemic Associations of Conjunctival and Corneal Tumors
Arun D. Singh and Elias I. Traboulsi —
SECTION 4 Uveal Tumors
Chapter 31 Examination Techniques
Nikolaos Trichopoulos and Bertil E. Damato
Chapter 32 Diagnostic Techniques
Sophie Bakri, LuAnne Sculley, and Arun D. Singh
Chapter 33 Classification of Uveal Tumors
Bertil E. Damato, Sarah E. Coupland, and Paul Hiscott
Chapter 34 Tumors of the Uvea: Benign Melanocytic Tumors
Arun D. Singh
Chapter 35 Uveal Malignant Melanoma: Epidemiologic Aspects
Arun D. Singh, Louise Bergman, and Stefan Seregard
Chapter 36 Uveal Malignant Melanoma: Clinical Features
Leonidas Zografos
Chapter 37 Uveal Malignant Melanoma: Differential Diagnosis
Devron H. Char
Chapter 38 Uveal Malignant Melanoma: Histopathologic Features
Tero Kivelä
Chapter 39 Management of Patients With Uveal Melanoma
Bertil E. Damato
Chapter 40 Uveal Malignant Melanoma: Management Options—Thermotherapy
Hanneke J. G. Journée-de Korver, Nicoline E. Schalij-Delfos, and Saskia M. Imhof
Chapter 41 Uveal Malignant Melanoma: Management Options—Brachytherapy
Stefan Seregard, Bertil E. Damato, and Peter Fleming
Chapter 42 Uveal Malignant Melanoma: Management Options—Proton Beam Radiotherapy
Anne Marie Lane and Evangelos S. Gragoudas
Chapter 43 Uveal Malignant Melanoma: Management Options—Stereotactic Radiotherapy
Karin Dieckmann, Gerald Langmann, Roy Ma, Mona Schmutzer, Richard Poetter, Werner Wackernagel, and Martin Zehetmayer
Chapter 44 Uveal Malignant Melanoma: Management Options—Re
Bertil E. Damato and Carl Groenewald
Chapter 45 Uveal Malignant Melanoma: COMS Results
Arun D. Singh and Tero Kivelä
Chapter 46 Uveal Malignant Melanoma: Prognostic Factors
Robert Folberg and Jacob Pe’er
Chapter 47 Uveal Malignant Melanoma: Mortality
Bertil E. Damato and Azzam Taktak
Chapter 48 Uveal Malignant Melanoma: Metastasis
Arun D. Singh, Julie Bray, and Ernest C. Borden
Chapter 49 Uveal Vascular Tumors
Arun D. Singh and Peter K. Kaiser
Chapter 50 Uveal Neural Tumors
Arun D. Singh and Jonathan E. Sears
Chapter 51 Uveal Osseous Tumors
Arun D. Singh
Chapter 52 Uveal Myogenic, Fibrous, and Histiocytic Tumors
Paul Rundle, Hardeep Singh Mudhar, M. Andrew Parsons, and Ian G. Rennie
Chapter 53 Uveal Lymphoproliferative Tumors
Sarah E. Coupland
Chapter 54 Uveal Metastatic Tumors
Norbert Bornfeld
Chapter 55 Intraocular Manifestations of Proliferative Hematopoietic Disorders
Hayyam Kiratli
Chapter 56 Intraocular Biopsy
Devron H. Char
SECTION 5 Tumors of the Retina and Retinal Pigment Epithelium
Chapter 57 Retinal Vascular Tumors
Arun D. Singh, Paul Rundle, and Ian G. Rennie
Chapter 58 Coats Disease
Thomas M. Aaberg, Jr
Chapter 59 Retinal Astrocytic Tumors
Mehryar Taban, Mehran Taban, and Arun D. Singh
Chapter 60 Tumors of the Retinal Pigment Epithelium
Elias I. Traboulsi, Martin Heur, and Arun D. Singh
Chapter 61 Tumors of the Ciliary Pigment Epithelium
Javier Elizalde, María de la Paz, and Rafael I. Barraquer
Chapter 62 Lymphoma of the Retina and Central Nervous System
Arun D. Singh, Hilel Lewis, Andrew P. Schachat, and David Peereboom
Chapter 63 Ocular Paraneoplastic Diseases
Rishi P. Singh and Arun D. Singh
Chapter 64 Neuro-Oculocutaneous Syndromes (Phakomatoses)
Arun D. Singh, Elias I. Traboulsi, and Lynn Schoenfield
SECTION 6 Retinoblastoma
Chapter 65 Retinoblastoma and Cancer Genetics
Alfred G. Knudson, Jr
Chapter 66 Genetic and Cellular Events in Retinoblastoma
Michael A. Dyer and J. William Harbour
Chapter 67 Geographic and Environmental Factors
Greta R. Bunin and Manuela Orjuela
Chapter 68 Retinoblastoma: An International Perspective
Guillermo L. Chantada and Carlos Leal-Leal
Chapter 69 Staging and Grouping of Retinoblastoma
A. Linn Murphree and Guillermo L. Chantada
Chapter 70 Heritable Retinoblastoma: The RB1 Cancer Predisposition Syndrome
A. Linn Murphree and Arun D. Singh
Chapter 71 Non-Ocular Tumors
Cari E. Lyle, Carlos Rodriguez-Galindo, and Matthew W. Wilson
Chapter 72 Trilateral Retinoblastoma
Cari E. Lyle, Carlos Rodriguez-Galindo, and Matthew W. Wilson
Chapter 73A Genetic Testing and Counseling
Robin D. Clark and Nancy C. Mansfield
Chapter 73B Family Counseling
Nancy C. Mansfield and Robin D. Clark
Chapter 74 Chemotherapy for Retinoblastoma: An Overview
Rima F. Jubran, Judith G. Villablanca, and Anna T. Meadows
Chapter 75 Local Therapy, Brachytherapy, and Enucleation
A. Linn Murphree
Chapter 76 Teletherapy: Indications, Risks, and New Delivery Options
Thomas E. Merchant
Chapter 77 Histopathologic Features and Prognostic Factors
Patricia Chévez-Barrios, Ralph C. Eagle, Jr, and Eduardo F. Marback
Chapter 78 Orbital Retinoblastoma
Santosh G. Honavar
Chapter 79 Metastatic Retinoblastoma
Ira J. Dunkel and Guillermo L. Chantada
Chapter 80 Retinocytoma or Retinoma
Arun D. Singh, Aubin Balmer, and Francis Munier
Chapter 81 Children's Oncology Group Trials for Retinoblastoma
Anna T. Meadows, Murali Chintagumpala, Ira J. Dunkel, Debra Friedman, Julie A. Stoner, and Judith G. Villablanca
Chapter 82 Retinoblastoma: At-Risk Pregnancies
Lisa Paquette and David A. Miller
Chapter 83 Future Directions
A. Linn Murphree
SECTION 7 Orbital Tumors
Chapter 84 Examination Techniques
Mehryar Taban and Julian D. Perry
Chapter 85 Imaging Techniques
Patrick De Potter
Chapter 86 Classification of Orbital Tumors
Mehran Taban and Julian D. Perry
Chapter 87 Evaluation of a Child With Orbital Tumor
Paul L. Proffer, Jill A. Foster, and Julian D. Perry
Chapter 88 Evaluation of an Adult With Orbital Tumor
Benson Chen, Julian D. Perry, and Jill A. Foster
Chapter 89 Non-Specific Orbital Inflammation
Roberta E. Gausas, Kimberly Cockerham, and Madhura Tamhankar
Chapter 90 Vascular Orbital Tumors
Benson Chen and Julian D. Perry
Chapter 91 Benign Tumors of the Orbit
Bhupendra Patel
Chapter 92 Tumors of the Optic Nerve
Jonathan Dutton
Chapter 93 Tumors of the Lacrimal Gland
Omar M. Durrani and Geoffrey E. Rose
Chapter 94 Tumors of the Lacrimal Sac
Jacob Pe’er
Chapter 95 Orbital and Adnexal Lymphoma
David S. Bardenstein
Chapter 96 Malignant Tumors of the Orbit
Bhupendra Patel
Chapter 97 Rhabdomyosarcoma
Benson Chen and Julian D. Perry
Chapter 98 Enucleation and Orbital Implants
David R. Jordan and Stephen R. Klapper
Chapter 99 Principles of Orbital Surgery
José Perez-Moreiras, Javier Coloma, and Consuelo Prada
Index