Allergic Disease Mechanisms

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Quilizumab appears tolerable, reduces serum IgE levels

April 25, 2016

Patients in this study who received quilizumab had reduced serum immunoglobulin E levels and appeared to tolerate the humanized IgG1 monoclonal antibody well, according to recent research published in Respiratory Research.

“In adults with uncontrolled allergic asthma, a 36-week treatment with quilizumab, an anti–M1-prime monoclonal antibody that targets [immunoglobulin E] IgE-switched and IgE memory B cells, did not result in a clinically significant impact on exacerbation rate, lung function, or quality of life,” Jeffrey M. Harris, MD, PhD, from Genentech, Inc. in San Francisco, and colleagues wrote in their study. “Our data on quilizumab activity indicate that there are major pathological mechanisms that extend beyond the new, local production of IgE in patients with inadequately controlled allergic asthma.”

In the Journals

Novel IRF2BP2 mutation linked to CVID–like immunodeficiency

April 15, 2016
Researchers identified a novel mutation in IRF2BP2 in a family with a history of common variable immunodeficiency disorder, which may be the cause of the disease…
In the Journals

Inflammatory endotypes help to identify chronic rhinosinusitis

April 12, 2016
Researchers in this study identified correlations between phenotypes and inflammatory endotypes in patients with chronic rhinosinusitis which may aid in a more accurate…
In the Journals

Similar patterns in Vβ TCR seen in healthy, atopic children

April 4, 2016
Researchers in this study found a similar pattern of V segments in the beta chain of T-cell regulators among atopic and healthy patients, according to research…
Meeting News Coverage

Siblings of allergic children often show food sensitivities not allergies

November 6, 2015
SAN ANTONIO — Siblings of children with food allergies were likely to have food sensitivity, but not likely to have the same food allergies…

In the Journals

Tobacco smoke, IgE sensitization leaves children susceptible to environmental allergens

October 29, 2015
Children exposed to tobacco smoke may have altered immunoglobulin E–mediated immune responses that may make them more sensitive to…

In the Journals

Novel SNPs identified for bone mineral accretion in children

June 24, 2015
Two novel tubulin pathway single nucleotide polymorphisms were associated with independent interactive effects of cumulative corticosteroid dose on…

In the Journals

Algorithm for CRS classification may predict recurrence risk, refractoriness

June 23, 2015
A diagnostic algorithm for classifying chronic rhinosinusitis demonstrated utility in determining refractoriness and recurrence risk for the…

In the Journals

Urbanization affects development of allergen sensitization among elderly

April 13, 2015
Urbanization was linked with self-reported rhinitis symptoms and sensitization to inhalant allergens in an elderly South Korean population, according…

In the Journals

Breast-feeding does not affect allergy sensitization in children

April 10, 2015
The time a mother spends breast-feeding her child has no impact on the development of allergy sensitization in children at high risk for developing…

Meeting News Coverage

Tiotropium improves lung function in asthma, regardless of allergic status

February 26, 2015
HOUSTON — The addition of tiotropium Respimat in adult patients with mild, moderate and severe asthma improved lung function independent of…

Meeting News CoverageVideo

VIDEO: 3 things to know from AAAAI 2015

February 22, 2015
HOUSTON — Mary Beth Fasano, MD, FAAAAI, vice chair of the annual meeting programming committee, spoke to about key…

Meeting News CoveragePerspective

Microbial environmental factors increase childhood allergic disease risk

February 21, 2015
HOUSTON — Microbial environmental exposures play a role in defining the risk for childhood allergic airway disease, according to Susan V

Meeting News Coverage

AAAAI annual meeting to showcase new discoveries, treatments

February 20, 2015 will present live coverage of the American Academy of Allergy, Asthma and Immunology annual meeting today through Feb. 24 in Houston. The…

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