Allergic Disease Mechanisms

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Quilizumab appears tolerable, reduces serum IgE levels

April 25, 2016

Patients in this study who received quilizumab had reduced serum immunoglobulin E levels and appeared to tolerate the humanized IgG1 monoclonal antibody well, according to recent research published in Respiratory Research.

“In adults with uncontrolled allergic asthma, a 36-week treatment with quilizumab, an anti–M1-prime monoclonal antibody that targets [immunoglobulin E] IgE-switched and IgE memory B cells, did not result in a clinically significant impact on exacerbation rate, lung function, or quality of life,” Jeffrey M. Harris, MD, PhD, from Genentech, Inc. in San Francisco, and colleagues wrote in their study. “Our data on quilizumab activity indicate that there are major pathological mechanisms that extend beyond the new, local production of IgE in patients with inadequately controlled allergic asthma.”

In the Journals

Novel IRF2BP2 mutation linked to CVID–like immunodeficiency

April 15, 2016
Researchers identified a novel mutation in IRF2BP2 in a family with a history of common variable immunodeficiency disorder, which may be the cause of the disease…
In the Journals

Inflammatory endotypes help to identify chronic rhinosinusitis

April 12, 2016
Researchers in this study identified correlations between phenotypes and inflammatory endotypes in patients with chronic rhinosinusitis which may aid in a more accurate…
In the Journals

Similar patterns in Vβ TCR seen in healthy, atopic children

April 4, 2016
Researchers in this study found a similar pattern of V segments in the beta chain of T-cell regulators among atopic and healthy patients, according to research…
In the Journals

Quilizumab appears tolerable, reduces serum IgE levels

April 25, 2016
Patients in this study who received quilizumab had reduced serum immunoglobulin E levels and appeared to tolerate the humanized IgG1 monoclonal…

In the Journals

Novel IRF2BP2 mutation linked to CVID–like immunodeficiency

April 15, 2016
Researchers identified a novel mutation in IRF2BP2 in a family with a history of common variable immunodeficiency disorder, which may be the cause of…

In the Journals

Inflammatory endotypes help to identify chronic rhinosinusitis

April 12, 2016
Researchers in this study identified correlations between phenotypes and inflammatory endotypes in patients with chronic rhinosinusitis which may aid…

In the Journals

Similar patterns in Vβ TCR seen in healthy, atopic children

April 4, 2016
Researchers in this study found a similar pattern of V segments in the beta chain of T-cell regulators among atopic and healthy patients, according…

In the Journals

Genetic link to cow's milk allergy may predict later allergic onset

March 30, 2016
Researchers have identified two single nucleotide polymorphisms associated with cow’s milk allergy in pediatric patients that may pave the way…

In the Journals

Patients in Cameroon show high sensitization to aeroallergens

March 29, 2016
A significant proportion of patients in Cameroon showed a sensitization to aeroallergens, including dust mites and cockroaches, according to recent…

In the Journals

IgE observed in just half of UK children with food hypersensitivity

March 22, 2016
Researchers found immunoglobulin E-mediated food allergy in just half of observed children in a recent population based birth cohort study. Further…

In the Journals

Handbook improves parental knowledge of child’s food allergy

March 17, 2016
Parents of pediatric patients with food allergies who received a food allergy handbook showed better knowledge, confidence and quality of life in…

In the Journals

Food allergy in adolescents linked to emotional, behavioral problems

February 25, 2016
Adolescents with food allergies are also more likely to have emotional and behavioral problems such as attention deficit hyperactivity disorder…

In the Journals

Allergic diseases at age 4 predict increased risk for developing internalizing behaviors at age 7

January 13, 2016
Young patients with allergic diseases such as allergic rhinitis and allergic persistent wheezing are significantly more likely to develop…

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