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Long-acting beta agonists not superior to tiotropium in black adults with asthma

November 25, 2015

Black adults with asthma treated with long-acting beta-agonists plus inhaled corticosteroids demonstrated no improvement in time to asthma exacerbation compared with those who received tiotropium plus inhaled corticosteroids, according to results of a randomized clinical trial.

Michael E. Wechsler, MD, MSc, of Brigham and Women’s Hospital, and colleagues sought to determine the effectiveness and safety of adding tiotropium to inhaled corticosteroids vs. adding long-acting beta agonists in the treatment of black adults with asthma. Further, the researchers examined whether there exists an association of allelic variation at the Arg16Gly locus of the beta 2-andrenergic receptor (ADRB2) gene in treatment response.

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