January 27, 2015
High use of anticholinergic medications such as antihistamines and antidepressants may increase the risks for dementia and Alzheimer’s disease in the elderly, according to study results.
Shelly L. Gray, PharmD, MS, of the University of Washington School of Pharmacy, and colleagues conducted a population-based prospective cohort study on participants from the Adult Changes in Thought study. Study participants (median age at enrollment, 74.4 years) were randomly sampled Seattle-area Group Health members recruited from 1994 to 1996. Additional participants were enrolled from 2000 to 2003.