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Obese patients with esophageal cancer who underwent chemoradiotherapy did not experience worse disease outcomes and had reduced risk for high-grade esophagitis, hematologic toxicity and esophageal stricture compared with patients with lower BMI in a recent study.
Researchers at the University of Texas MD Anderson Cancer Center retrospectively identified 405 patients with nonmetastatic esophageal cancer between March 2002 and April 2010. All had received chemotherapy and radiotherapy with or without surgery, and were categorized as either obese (n=290; BMI≥25 kg/m2) or nonobese (n=115; BMI<25 kg/m2). Progression-free survival (PFS), overall survival (OS) and pathologic complete response (pCR) were determined using Cox proportional hazards regression and Kaplan-Meier analyses.
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