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Novel multiple sclerosis drug RPC1063 shows potential for treating UC

October 31, 2014

RPC1063, a sphingosine 1-phosphate 1 receptor small molecule modulator candidate for immune indications such as relapsing multiple sclerosis, demonstrated safety and efficacy in the treatment of patients with ulcerative colitis in a recent phase 2 clinical trial, according to a press release from the manufacturer.

The TOUCHSTONE trial included 199 patients with moderately to severely active UC from 57 centers in 13 countries who were randomly assigned 0.5 mg or 1 mg RPC1063 (Receptos) or placebo. There was an 8-week induction period followed by a 24-week maintenance period, which is ongoing and scheduled to be completed in 2015. Clinical remission was achieved at week 8 by 16.4% of patients in the 1-mg group vs. 6.2% of the placebo group (P<.05), and 13.8% of the 0.5-mg group achieved clinical remission. Clinical response was achieved by 58.2% of patients in the 1-mg group compared with 36.9% of the placebo group (P<.05). Positive changes in Mayo score and mucosal improvement also were achieved by patients in the 1-mg group, and similar trends were observed in the 0.5-mg group. RPC1063 also appeared to be well tolerated.

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NAFLD associated with severe acute pancreatitis

October 31, 2014
PHILADELPHIA — Patients with nonalcoholic fatty liver disease had a greater prevalence of moderate to severe acute pancreatitis compared with patients without…

Omeros granted CMS pass-through reimbursement status for Omidria

October 31, 2014
The Center for Medicare and Medicaid Services has granted Omeros Corporation with transitional pass-through status for Omidria 1%/0.3%, according to an Omeros press…
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BLOG: Day 2 of ATA highlights fellow lectures, start of Meet-the-Professor sessions

October 31, 2014
CORONADO, Calif. — Day 2 of the American Thyroid Association Annual Meeting consisted of lectures for fellows participating in the Trainees’ grant program…
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Journal of Psychosocial Nursing and Mental Health Services Oct 2014 CNE Activity

This activity is co-provided by Villanova University College of Nursing and SLACK Incorporated.

Topics include simulation in psychiatric nursing education.
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Major Article

Professional Socialization of Students in Clinical Nurse Specialist Programs

Journal of Nursing Education
Online Advanced Release, October 27, 2014
Graduate nursing programs facilitate the transition of RNs to advanced roles through a complex process of professional…
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Endocrine research advances ‘raise more questions than answers’

October 30, 2014
CORONADO, Calif. — Possible birth defects caused by propylthiouracil (PTU) and methimazole and the efficacy of…
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