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Fracture risk highest for children, adolescents with osteogenesis imperfecta

August 31, 2016

Danish patients with osteogenesis imperfecta have an increased fracture rate throughout their lives vs. those without the disease, with the highest fracture rate observed during their first two decades of life, according to findings from a population-based, cohort study.

“We saw the highest rates of forearm, femur and lower leg and ankle fractures in the youngest age group,” Lars Folkestad, MD, of the department of endocrinology at Odense University Hospital in Kloevervaenget, Denmark, and colleagues wrote. “This indicates that children with [osteogenesis imperfecta] are likely to be more susceptible to long-bone fractures when they start to walk and become more active. We would speculate that the [discordance] in bone strength and growth could explain some of the increased fracture rates seen in patients with [osteogenesis imperfecta] during the first two decades of life.”

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