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Dabrafenib plus trametinib demonstrates long-term tolerability in BRAF V600–mutated melanoma

March 24, 2017

NEW YORK — Extended treatment with dabrafenib plus trametinib demonstrated consistent tolerability profiles in patients with BRAF V600–mutant melanoma, according to a pooled analysis presented at HemOnc Today Melanoma and Cutaneous Malignancies.

The phase 3 COMBI-d and COMBI-v studies — designed to evaluate dabrafenib (Tafinlar, Novartis), a BRAF kinase inhibitor, plus trametinib (Mekinist, Novartis), a MEK inhibitor — showed tolerability and efficacy with the combination with a median follow-up of 20.2 months.

DOC Access Act strives to end anticompetitive practices by vision plans

March 24, 2017
The Dental and Optometric Care Access Act, which seeks to empower doctors and patients in their dealings with vision plans, eliminate a growing level of anticompetitive…
In the Journals

Survey: Sustained-release dexamethasone insert earns high satisfaction rating from cataract patients

March 24, 2017
Subjective quality assessment of a sustained-release dexamethasone intracanalicular insert showed a high degree of patient satisfaction regarding comfort, convenience…
Meeting News

Strategies to detect immune-based biomarkers evolving for melanoma treatment

March 24, 2017
NEW YORK — Several blood- and tissue-based assays are in development to identify appropriate treatment options for patients with melanoma, according to a speaker…
In the Journals Plus

Stress fracture risk varies by race, sex

March 24, 2017
White U.S. Army soldiers were more likely to sustain a stress fracture over 10 years vs. soldiers of other races, with the highest risk observed among white women…
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CME

HPV Immunization: Ensuring Your Patients Do Not Slip through the Cracks

This activity is supported by an educational grant from Merck & Co., Inc.

Vaccination rates for the human papillomavirus (HPV) continue to be below those of other vaccines recommended for…
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Feature Article

Biomechanical Analysis of Intervertebral Cement Extravasation in Vertebral Motion Segments

Orthopedics, March/April 2017, Volume 40 Issue 2
Kyphoplasty is a therapeutic option for pain relief in the setting of compression fractures. Cement extravasation into…
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American Academy of Dermatology Meeting

American Academy of Dermatology Meeting

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Meeting News

VIDEO: Presenter discusses outcomes after arthroscopy for acute, chronic labral tears in adolescents

March 23, 2017
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