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Researchers compare CCP profile of patients with JIA vs RA

April 26, 2017

Among patients with rheumatoid arthritis and patients with a polyarticular subtype of juvenile idiopathic arthritis, researchers at University College London compared profiles of antibodies to cyclic citrullinated peptide profiles.

“[This] study has demonstrated the novel finding that adolescent [rheumatoid factor-positive polyarticular juvenile idiopathic arthritis] pJIA (RF+ve) patients are distinct in their anti-[cyclic citrullinated protein] CCP antibody phenotype from other JIA clinical patterns and age/sex matched healthy controls; but are comparable to adult RF-positive patients in their levels of IgG anti-CCP and shared expression of the same inherently autoreactive 9G4 idiotype,” Yiannis Ioannou, PhD, at the Arthritis Research UK Centre for Adolescent Rheumatology at University College London, and colleagues wrote. “However, it was found that the adult group had significantly higher levels of IgA and IgM anti-CCPs than the adolescent group, suggesting that further investigation is needed to fully elucidate the extent to which these two conditions may be seen as one.”

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CNE CME

The Identification and Management of Immune-related Adverse Events in Patients with Cancer: Practice Essentials for Emergency Medicine Providers

This activity is supported by an educational grant from Bristol-Myers Squibb.

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Original ResearchOpen Access

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