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Cariprazine safely, effectively treats negative schizophrenia symptoms

September 3, 2015

Negative symptoms of schizophrenia — withdrawal, lack of emotion and apathy — may be treatable with cariprazine, according to results from a phase 3 clinical trial presented at the European College of Neuropsychopharmacology Congress annual meeting.

“Cariprazine, a dopamine D3/D2 receptor partial agonist with preference for D3 receptors, has demonstrated efficacy for the treatment of schizophrenia, including in three 6-week, randomized, double-blind, placebo-controlled, phase 2/3 clinical trials in patients with acute psychotic exacerbations and in one relapse prevention clinical trial in stabilized patients. Post hoc analysis of the 6-week efficacy trials on a subset of patients with high levels of negative symptoms demonstrated significantly greater improvement relative to placebo,” the researchers wrote.

Meeting News Coverage

Early, sensitive troponin I assessment safe, effective for acute MI diagnosis

September 3, 2015
LONDON — A new algorithm incorporating a more sensitive cutoff for troponin I values to identify non-STEMI would result in lower mortality and allow more rapid…
In the Journals

Hydrophobic acrylic IOL associated with increase in PCO up to 3 years

September 3, 2015
A single-piece hydrophobic acrylic IOL was associated with a significant increase in posterior capsule opacification up to 3 years and stabilization between 3 years and…
In the Journals

Phthalate exposure linked to miscarriage

September 3, 2015
Miscarriage, particularly between 5 and 13 weeks of pregnancy, has been linked to exposure to certain phthalates, according to recent study findings published in…
MicroRNA target gene may be linked to NAFLD-related fibrosis In the Journals

MicroRNA target gene may be linked to NAFLD-related fibrosis

September 3, 2015
Researchers from the Translational Genomics Research Institute found a potential gene within microRNAs that may be linked to nonalcoholic fatty liver disease-related…
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CME
Gastroenterology Case Consults

The Patient with Metabolic Liver Disease

No commercial support for this activity.

This CME activity will focus on the diagnosis and management of patients with lysosomal acid lipase deficiency.
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Original Article

Supporting Graduate Nurse Transition: Collaboration Between Practice and University

The Journal of Continuing Education in Nursing, September 2015, Volume 46 Issue 9
Making the transition from student to RN is challenging and demanding. In Australia, where nurses commonly graduate…
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Meeting News Coverage Video
VIDEO: ARTS-HF results indicate benefits of finerenone for certain patients with HF

VIDEO: ARTS-HF results indicate benefits of finerenone for certain patients with HF

September 2, 2015
LONDON — In this video, Richard A. Chazal, MD, FACC, medical director of the Heart and Vascular Institute at Lee…
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